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Difference in Hepatic Metabolism of Long- and Medium-Chain Fatty Acids: the Role of Fatty Acid Chain Length in the Production of the Alcoholic Fatty Liver*

机译:长链和中链脂肪酸肝脏代谢的差异:脂肪酸链长在酒精性脂肪肝生产中的作用*

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摘要

Replacement of dietary triglycerides containing long-chain fatty acids (LCFA) by triglycerides containing medium-chain fatty acids (MCFA) markedly reduced the capacity of alcohol to produce fatty liver in rats. After 24 days of ethanol and MCFA, the increase in hepatic triglycerides was only 3 times that of controls, whereas an 8-fold rise was observed after ethanol and LCFA. The triglyceride fatty acids that accumulated in the liver after feeding of ethanol with MCFA contained only a small percentage of the MCFA; their composition also differed strikingly from that of adipose lipids.
机译:用含有中链脂肪酸的甘油三酸酯(MCFA)替代含有长链脂肪酸的饮食甘油三酸酯显着降低了大鼠酒精生产脂肪肝的能力。乙醇和MCFA处理24天后,肝甘油三酯的增加仅为对照的3倍,而乙醇和LCFA处理后肝甘油三酯的增加为8倍。用乙醇饲喂MCFA后,肝脏中积累的甘油三酸酯脂肪酸仅占MCFA的一小部分。它们的组成也与脂肪脂质显着不同。

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